学者简介
男，1961年生于江西，1986年中国协和医科大学研究生毕业，1992、1994、1996在德国联邦药物所从事过短期访问研究，2001-2002年美国弗吉尼亚大学高级访问学者。现任北京大学临床肿瘤学院教授，病因研究室主任、博士生导师，国务院特贴专家，中国抗癌协会病因专业委员会副主任委员。主要立足国内，先后承担国家科技攻关、863、973、国家自然科学基金项目和部市级等科研项目20余项。率先证明食品和人胃内能够亚硝化合成致癌性N-亚硝基脲类亚硝酰胺，首创变性高效液相色谱（DHPLC）定性和定量检测CpG岛甲基化技术,在胃癌和胰岛素瘤的表遗传学变异研究上做出了成绩。在《J Agric Food Chem》、《Nucleic Acids Res》、《Carcinogenesis》、《J Dent Res》、《Mutat Res》、《Clin Cancer Res》和《Lab Invest》等刊物发表论著50余篇，出版《癌变原理研究》专著一部，获得国家和北京市科技进步奖4项，申请国家和国际发明专利4项。
主要学术论著
Silencing-specific methylation and single nucleotide polymorphism
progress of gastric cancer etiology： N-nitrosamides
Simultaneous detection of CpG methylation and single nucleotide polymorphism by denaturing high performance liquid chromatography
p16 hypermethylation during gastric carcinogenesis of Wistar rats by N-methyl-N'-nitro-N-nitrosoguanidine
Formation of A2143G Mutation of 23S rRNA in Progression of Clarithromycin Resistance in Helicobacter pylori 26695
Methylation of CpG islands of p16 associated with progression of primary gastric carcinomas
Destruction of Parotid Glands Affects Nitrate and Nitrite Metabolism
Characterization of N-(Nitrosomethyl)urea in Nitrosated Fermented Fish Products
Formation of N-(Nitrosomethyl)urea in Stomachs of Experimental Pigs and Human Volunteers Given Fish Sauce in Vivo
SHORT TANDEM REPEAT POLYMORPHISM IN A NOVEL ESOPHAGEAL CANCER-RELATED GENE (ECRG2) IMPLICATES SUSCEPTIBILITY TO ESOPHAGEAL CANCER IN CHINESE POPULATION
Genetic Variants in Cyclooxygenase-2： Expression and Risk of Gastric Cancer and Its Precursors in a Chinese Population
INDUCTION OF GASTRIC INTRAEPITHELIAL NEOPLASIA OF GLANDULAR STOMACH OF MONGOLIAN GERBILS BY HELICOBACTER PYLORI
Methylation of p16 CpG Islands Associated with Malignant Transformation of Gastric Dysplasia in a Population-Based Study
Hypermethylation of metallothionein-3 CpG island in gastric carcinoma
学者联系方式
单位名称：北京大学
联系地址：海淀区阜成路52号
邮政编码：100036
